Central Role of the Threonine Residue within the p+1 Loop of Receptor Tyrosine Kinase in STAT3 Constitutive Phosphorylation in Metastatic Cancer Cells

The receptor tyrosine kinases (RTKs) RET, MET, and RON all carry the Met(p+1loop)→Thr point mutation (i.e., 2B mutation), leading to the formation of tumors with high metastatic potential. Utilizing a novel antibody array, we identified constitutive phosphorylation of STAT3 in cells expressing the 2...

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Autores principales: Yuan, Zheng-long, Guan, Ying-jie, Wang, Lijuan, Wei, Wenyi, Kane, Agnes B., Chin, Y. Eugene
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC522220/
https://ncbi.nlm.nih.gov/pubmed/15485908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9390-9400.2004
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