Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A (11)C-donepezil PET Study

OBJECTIVE(S): It is difficult to investigate the whole-body distribution of an orally administered drug by means of positron emission tomography (PET), owing to the short physical half-life of radionuclides, especially when (11)C-labeled compounds are tested. Therefore, we aimed to examine the whole...

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Veröffentlicht in:Asia Ocean J Nucl Med Biol
Hauptverfasser: Mochida, Ikuko, Shimosegawa, Eku, Kanai, Yasukazu, Naka, Sadahiro, Matsunaga, Keiko, Isohashi, Kayako, Horitsugi, Genki, Watabe, Tadashi, Kato, Hiroki, Hatazawa, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Asia Oceania Journal of Nuclear Medicine & Biology 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221682/
https://ncbi.nlm.nih.gov/pubmed/28840133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/aojnmb.2016.7513
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