Distribution of Intravenously Administered Acetylcholinesterase Inhibitor and Acetylcholinesterase Activity in the Adrenal Gland: (11)C-Donepezil PET Study in the Normal Rat

PURPOSE: Acetylcholinesterase (AChE) inhibitors have been used for patients with Alzheimer's disease. However, its pharmacokinetics in non-target organs other than the brain has not been clarified yet. The purpose of this study was to evaluate the relationship between the whole-body distributio...

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Main Authors: Watabe, Tadashi, Naka, Sadahiro, Ikeda, Hayato, Horitsugi, Genki, Kanai, Yasukazu, Isohashi, Kayako, Ishibashi, Mana, Kato, Hiroki, Shimosegawa, Eku, Watabe, Hiroshi, Hatazawa, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166663/
https://ncbi.nlm.nih.gov/pubmed/25225806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107427
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