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Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1-42 Aggregation
Preventing and treating Alzheimer’s disease require understanding the aggregation of amyloid beta 1-42 (Aβ(1-42)) to give oligomers, protofibrils, and fibrils. Here we describe footprinting of Aβ(1-42) by hydroxyl radical-based fast photochemical oxidation of proteins (FPOP) and mass spectrometry (M...
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| Gepubliceerd in: | J Am Chem Soc |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5221481/ https://ncbi.nlm.nih.gov/pubmed/27568528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07543 |
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