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Optimization of Combinatorial Mutagenesis
Protein engineering by combinatorial site-directed mutagenesis evaluates a portion of the sequence space near a target protein, seeking variants with improved properties (e.g., stability, activity, immunogenicity). In order to improve the hit-rate of beneficial variants in such mutagenesis libraries...
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| Publié dans: | J Comput Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Mary Ann Liebert, Inc.
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5220575/ https://ncbi.nlm.nih.gov/pubmed/21923411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2011.0152 |
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