The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

Presenilins (PSs) are required for Notch signaling in the development of vertebrates and invertebrates. Mutations in human PS1 and PS2 homologs are a cause of familial Alzheimer's disease (AD). The function of the recently identified ancient family of IMPAS proteins (IMP/SPP/PSH) homologous to...

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Bibliografiske detaljer
Main Authors: Grigorenko, Anastasia P., Moliaka, Yuri K., Soto, Martha C., Mello, Craig C., Rogaev, Evgeny I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC522053/
https://ncbi.nlm.nih.gov/pubmed/15469912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406462101
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