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Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin

Melanoma is a cancer with a rising incidence, and metastatic disease is almost always lethal. We investigated the feasibility of targeting melanin, an intracellular melanocyte pigment, to deliver cytotoxic radiation to human melanoma cells in vivo by using a melanin-binding mAb (6D2). Nude mice bear...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dadachova, Ekaterina, Nosanchuk, Joshua D., Shi, Li, Schweitzer, Andrew D., Frenkel, Annie, Nosanchuk, Jerome S., Casadevall, Arturo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC522038/
https://ncbi.nlm.nih.gov/pubmed/15469923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406180101
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