Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin

Melanoma is a cancer with a rising incidence, and metastatic disease is almost always lethal. We investigated the feasibility of targeting melanin, an intracellular melanocyte pigment, to deliver cytotoxic radiation to human melanoma cells in vivo by using a melanin-binding mAb (6D2). Nude mice bear...

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Detaylı Bibliyografya
Asıl Yazarlar: Dadachova, Ekaterina, Nosanchuk, Joshua D., Shi, Li, Schweitzer, Andrew D., Frenkel, Annie, Nosanchuk, Jerome S., Casadevall, Arturo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC522038/
https://ncbi.nlm.nih.gov/pubmed/15469923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406180101
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