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Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin

Melanoma is a cancer with a rising incidence, and metastatic disease is almost always lethal. We investigated the feasibility of targeting melanin, an intracellular melanocyte pigment, to deliver cytotoxic radiation to human melanoma cells in vivo by using a melanin-binding mAb (6D2). Nude mice bear...

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Detalhes bibliográficos
Principais autores: Dadachova, Ekaterina, Nosanchuk, Joshua D., Shi, Li, Schweitzer, Andrew D., Frenkel, Annie, Nosanchuk, Jerome S., Casadevall, Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC522038/
https://ncbi.nlm.nih.gov/pubmed/15469923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406180101
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