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Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency

Genetic defects in ammonia metabolism can produce irreversible damage of the developing CNS causing an impairment of cognitive and motor functions. We investigated alterations in behavior, synaptic plasticity and gene expression in the hippocampus and dorsal striatum of transgenic mice with systemic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chepkova, Aisa N., Sergeeva, Olga A., Görg, Boris, Haas, Helmut L., Klöcker, Nikolaj, Häussinger, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220341/
https://ncbi.nlm.nih.gov/pubmed/28067279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40190
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