Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes

Polypurine reverse-Hoogsteen (PPRH) oligonucleotides are non-modified DNA molecules composed of two mirror-symmetrical polypurine stretches linked by a five-thymidine loop. They can fold into reverse-Hoogsteen hairpins and bind to their polypyrimidine target sequence by Watson-Crick bonds forming a...

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Vydáno v:Sci Rep
Hlavní autoři: Solé, Anna, Delagoutte, Emmanuelle, Ciudad, Carlos J., Noé, Véronique, Alberti, Patrizia
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220335/
https://ncbi.nlm.nih.gov/pubmed/28067256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39898
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