Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins

Thymidylate synthase (TYMS) enzyme is an anti-cancer target given its role in DNA biosynthesis. TYMS inhibitors (e.g., 5-Fluorouracil) can lead to drug resistance through an autoregulatory mechanism of TYMS that causes its overexpression. Since G-quadruplexes (G4) can modulate gene expression, we se...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Aubets, Eva, J. Félix, Alex, Garavís, Miguel, Reyes, Laura, Aviñó, Anna, Eritja, Ramón, Ciudad, Carlos J., Noé, Véronique
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404261/
https://ncbi.nlm.nih.gov/pubmed/32708710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21145028
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