Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo

Stimulatory heterotrimeric G protein (Gs) transduces signals from various cell-surface receptors to adenylyl cyclases, which generate cAMP. The α subunit of Gs (Gsα) is encoded by GNAS (Gnas in mice), and heterozygous Gsα inactivating mutations lead to Albright hereditary osteodystrophy. The in vivo...

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Hlavní autoři: Bastepe, Murat, Weinstein, Lee S., Ogata, Naoshi, Kawaguchi, Hiroshi, Jüppner, Harald, Kronenberg, Henry M., Chung, Ung-il
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC522030/
https://ncbi.nlm.nih.gov/pubmed/15459318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405091101
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