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Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo
Stimulatory heterotrimeric G protein (Gs) transduces signals from various cell-surface receptors to adenylyl cyclases, which generate cAMP. The α subunit of Gs (Gsα) is encoded by GNAS (Gnas in mice), and heterozygous Gsα inactivating mutations lead to Albright hereditary osteodystrophy. The in vivo...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522030/ https://ncbi.nlm.nih.gov/pubmed/15459318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405091101 |
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