Lamellipodial actin mechanically links myosin activity with adhesion site formation

Cell motility proceeds by cycles of edge protrusion, adhesion and retraction. Whether these functions are coordinated by biochemical or biomechanical processes is unknown. We find that myosin II pulls the rear of the lamellipodial actin network, causing upward bending, edge retraction and initiation...

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Pubblicato in:Cell
Autori principali: Giannone, Gregory, Dubin-Thaler, Benjamin, Rossier, Olivier, Cai, Yunfei, Chaga, Oleg, Jiang, Guoying, Beaver, William, Döbereiner, Hans-Günther, Freund, Yoav, Borisy, Gary, Sheetz, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5219974/
https://ncbi.nlm.nih.gov/pubmed/17289574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.12.039
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