Lamellipodial actin mechanically links myosin activity with adhesion site formation

Cell motility proceeds by cycles of edge protrusion, adhesion and retraction. Whether these functions are coordinated by biochemical or biomechanical processes is unknown. We find that myosin II pulls the rear of the lamellipodial actin network, causing upward bending, edge retraction and initiation...

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Bibliographische Detailangaben
Veröffentlicht in:Cell
Hauptverfasser: Giannone, Gregory, Dubin-Thaler, Benjamin, Rossier, Olivier, Cai, Yunfei, Chaga, Oleg, Jiang, Guoying, Beaver, William, Döbereiner, Hans-Günther, Freund, Yoav, Borisy, Gary, Sheetz, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5219974/
https://ncbi.nlm.nih.gov/pubmed/17289574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.12.039
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