Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression

Uncovering new therapeutic targets for renal fibrosis holds promise for the treatment of chronic kidney diseases. Bromodomain and extra-terminal (BET) protein inhibitors have been shown to effectively ameliorate pathological fibrotic responses. However, the pharmacological effects and underlying mec...

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Bibliografiske detaljer
Udgivet i:Redox Biol
Main Authors: Zhou, Baoshang, Mu, Jiao, Gong, Yi, Lu, Caibao, Zhao, Youguang, He, Ting, Qin, Zhexue
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5219604/
https://ncbi.nlm.nih.gov/pubmed/28063381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.12.031
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