Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis

The penetration of daptomycin, a new lipopeptide antibiotic, into inflamed meninges ranged between 4.37 and 7.53% (mean, 5.97%). Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of −1.20 ± 0.32 Δlog(10) CFU/ml · h in the bacterial titer o...

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Bibliographic Details
Main Authors: Cottagnoud, Philippe, Pfister, Marc, Acosta, Fernando, Cottagnoud, Marianne, Flatz, Lukas, Kühn, Felix, Müller, Hans-Peter, Stucki, Armin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC521930/
https://ncbi.nlm.nih.gov/pubmed/15388454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.10.3928-3933.2004
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