Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis

The penetration of daptomycin, a new lipopeptide antibiotic, into inflamed meninges ranged between 4.37 and 7.53% (mean, 5.97%). Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of −1.20 ± 0.32 Δlog(10) CFU/ml · h in the bacterial titer o...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Cottagnoud, Philippe, Pfister, Marc, Acosta, Fernando, Cottagnoud, Marianne, Flatz, Lukas, Kühn, Felix, Müller, Hans-Peter, Stucki, Armin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15388454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.10.3928-3933.2004
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