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Caspofungin Uptake Is Mediated by a High-Affinity Transporter in Candida albicans

The uptake of the echinocandin drug caspofungin acetate in Candida albicans was evaluated at drug levels at or near the MIC for the organism. Maximal uptake was achieved in 10 min and was energy independent. A saturable transport system, consistent with a facilitated-diffusion carrier, was observed...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Paderu, Padmaja, Park, Steven, Perlin, David S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521903/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15388444/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.10.3845-3849.2004
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