A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

Improved treatments for chronic hepatitis C virus (HCV) infection are needed due to the suboptimal response rates and deleterious side effects associated with current treatment options. The triphosphates of 2′-C-methyl-adenosine and 2′-C-methyl-guanosine were previously shown to be potent inhibitors...

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Bibliographic Details
Main Authors: Olsen, David B., Eldrup, Anne B., Bartholomew, Linda, Bhat, Balkrishen, Bosserman, Michele R., Ceccacci, Alessandra, Colwell, Lawrence F., Fay, John F., Flores, Osvaldo A., Getty, Krista L., Grobler, Jay A., LaFemina, Robert L., Markel, Eric J., Migliaccio, Giovanni, Prhavc, Marija, Stahlhut, Mark W., Tomassini, Joanne E., MacCoss, Malcolm, Hazuda, Daria J., Carroll, Steven S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC521892/
https://ncbi.nlm.nih.gov/pubmed/15388457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.10.3944-3953.2004
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