A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

Improved treatments for chronic hepatitis C virus (HCV) infection are needed due to the suboptimal response rates and deleterious side effects associated with current treatment options. The triphosphates of 2′-C-methyl-adenosine and 2′-C-methyl-guanosine were previously shown to be potent inhibitors...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Olsen, David B., Eldrup, Anne B., Bartholomew, Linda, Bhat, Balkrishen, Bosserman, Michele R., Ceccacci, Alessandra, Colwell, Lawrence F., Fay, John F., Flores, Osvaldo A., Getty, Krista L., Grobler, Jay A., LaFemina, Robert L., Markel, Eric J., Migliaccio, Giovanni, Prhavc, Marija, Stahlhut, Mark W., Tomassini, Joanne E., MacCoss, Malcolm, Hazuda, Daria J., Carroll, Steven S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2004
Onderwerpen:
Antiviral Agents
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC521892/
https://ncbi.nlm.nih.gov/pubmed/15388457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.10.3944-3953.2004
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items