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Replacement of Thymidine by a Modified Base in the E. coli genome

Prokaryotic and eukaryotic genomic DNA is comprised of the four building blocks A, G, C and T. We have begun to explore the consequences of replacing a large fraction or all of a nucleoside in genomic DNA with a modified nucleoside. As a first step we have investigated the possibility of replacement...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Mehta, Angad P., Li, Han, Reed, Sean A., Supekova, Lubica, Javahishvili, Tsotne, Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218517/
https://ncbi.nlm.nih.gov/pubmed/27213685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b03904
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