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Replacement of 2’-deoxycytidine by 2’-deoxycytidine analogs in the E. coli genome

Several modified bases have been observed in the genomic DNA of bacteriophages, prokaryotes and eukaryotes that play a role in restriction systems and/or epigenetic regulation. In our efforts to understand the consequences of replacing a large fraction of a canonical nucleoside with a modified nucle...

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Dettagli Bibliografici
Pubblicato in:J Am Chem Soc
Autori principali: Mehta, Angad P., Li, Han, Reed, Sean A., Supekova, Lubica, Javahishvili, Tsotne, Schultz, Peter G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134732/
https://ncbi.nlm.nih.gov/pubmed/27762133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b09661
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