Structural and Virological Studies of the Stages of Virus Replication That Are Affected by Antirhinovirus Compounds

Pleconaril is a broad-spectrum antirhinovirus and antienterovirus compound that binds into a hydrophobic pocket within viral protein 1, stabilizing the capsid and resulting in the inhibition of cell attachment and RNA uncoating. When crystals of human rhinovirus 16 (HRV16) and HRV14 are incubated wi...

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Autores principales: Zhang, Ying, Simpson, Alan A., Ledford, Rebecca M., Bator, Carol M., Chakravarty, Sugoto, Skochko, Gregory A., Demenczuk, Tina M., Watanyar, Adiba, Pevear, Daniel C., Rossmann, Michael G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC521849/
https://ncbi.nlm.nih.gov/pubmed/15452226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.20.11061-11069.2004
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