Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma

Glioblastoma multiformes (GBMs) are high-grade astrocytomas and the most common brain malignancies. Primary GBMs are often associated with disturbed RAS signaling, and expression of oncogenic HRAS results in a malignant phenotype in glioma cell lines. Secondary GBMs arise from lower-grade astrocytom...

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發表在:Mol Cell Proteomics
Main Authors: Doll, Sophia, Urisman, Anatoly, Oses-Prieto, Juan A., Arnott, David, Burlingame, Alma L.
格式: Artigo
語言:Inglês
出版: The American Society for Biochemistry and Molecular Biology 2017
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217781/
https://ncbi.nlm.nih.gov/pubmed/27834733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.063883
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