PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells

BACKGROUND: Lymphatic metastasis, facilitated by lymphangiogenesis is a common occurrence in breast cancer, the molecular mechanisms remaining incompletely understood. We had earlier shown that cyclooxygenase (COX)-2 expression by human or murine breast cancer cells promoted lymphangiogenesis and ly...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Nandi, Pinki, Girish, Gannareddy V., Majumder, Mousumi, Xin, Xiping, Tutunea-Fatan, Elena, Lala, Peeyush K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217626/
https://ncbi.nlm.nih.gov/pubmed/28056899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-3018-2
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