Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions

We previously established that COX-2 overexpression promotes breast cancer progression and metastasis. As long-term use of COX-2 inhibitors (COX-2i) can promote thrombo-embolic events, we tested an alternative target, prostaglandin E2 receptor EP4 subtype (EP4), downstream of COX-2. Here we used the...

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發表在:Cancer Sci
Main Authors: Majumder, Mousumi, Xin, Xiping, Liu, Ling, Girish, Gannareddy V, Lala, Peeyush K
格式: Artigo
語言:Inglês
出版: BlackWell Publishing Ltd 2014
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462388/
https://ncbi.nlm.nih.gov/pubmed/24981602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12475
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