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Cell-to-cell variation in p53 dynamics leads to fractional killing
Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon-cancer cells in response to chemotherapy. We found that both surviving and dying cells reach similar levels of p...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5217463/ https://ncbi.nlm.nih.gov/pubmed/27062928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.03.025 |
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