Targeting α-synuclein for treating Parkinson’s disease: mechanistic and therapeutic considerations

Progressive neuronal cell loss in a small subset of brainstem and mesencephalic nuclei and widespread aggregation of the α-synuclein protein in the form of Lewy bodies and Lewy neurites are neuropathological hallmarks of Parkinson’s disease. Most cases occur sporadically, but mutations in several ge...

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Bibliografiska uppgifter
I publikationen:Lancet Neurol
Huvudupphovsmän: Dehay, Benjamin, Bourdenx, Mathieu, Gorry, Philippe, Przedborski, Serge, Vila, Miquel, Hunot, Stephane, Singleton, Andrew, Olanow, C. Warren, Merchant, Kalpana M., Bezard, Erwan, Petsko, Gregory A., Meissner, Wassilios G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217462/
https://ncbi.nlm.nih.gov/pubmed/26050140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(15)00006-X
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