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Schedule-dependent interaction between anticancer treatments
The oncogene MDMX is overexpressed in many cancers leading to suppression of the tumor suppressor p53. MDMX inhibitors therefore might help reactivate p53 and enhance the efficacy of DNA damaging drugs. However, we currently lack a quantitative understanding of how MDMX inhibition affects the p53 si...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5217461/ https://ncbi.nlm.nih.gov/pubmed/26965628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac5610 |
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