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Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells

FLT3 mutation is found in about 30% of acute myeloid leukemia (AML) patients and is associated with a poor prognosis. Several FLT3 inhibitors are undergoing investigation, while their clinical efficacies were lower than expected and several resistant mechanisms to FLT3 inhibitors have been demonstra...

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Pubblicato in:Oncotarget
Autori principali: Chen, Fangli, Ishikawa, Yuichi, Akashi, Akimi, Naoe, Tomoki, Kiyoi, Hitoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216920/
https://ncbi.nlm.nih.gov/pubmed/27331411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10147
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