Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Miranda-Gonçalves, Vera, Granja, Sara, Martinho, Olga, Honavar, Mrinalini, Pojo, Marta, Costa, Bruno M., Pires, Manuel M., Pinheiro, Célia, Cordeiro, Michelle, Bebiano, Gil, Costa, Paulo, Reis, Rui M., Baltazar, Fátima
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216802/
https://ncbi.nlm.nih.gov/pubmed/27331625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10114
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge