Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Miranda-Gonçalves, Vera, Granja, Sara, Martinho, Olga, Honavar, Mrinalini, Pojo, Marta, Costa, Bruno M., Pires, Manuel M., Pinheiro, Célia, Cordeiro, Michelle, Bebiano, Gil, Costa, Paulo, Reis, Rui M., Baltazar, Fátima
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216802/
https://ncbi.nlm.nih.gov/pubmed/27331625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10114
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