Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

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Vydáno v:Oncotarget
Hlavní autoři: Miranda-Gonçalves, Vera, Granja, Sara, Martinho, Olga, Honavar, Mrinalini, Pojo, Marta, Costa, Bruno M., Pires, Manuel M., Pinheiro, Célia, Cordeiro, Michelle, Bebiano, Gil, Costa, Paulo, Reis, Rui M., Baltazar, Fátima
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216802/
https://ncbi.nlm.nih.gov/pubmed/27331625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10114
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