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Fibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1/secreted phosphoprotein 1-integrin signaling

The seeding of tumor cells is a critical step in the process of metastasis, but whether and how the microenvironment of target organs affects metastatic seeding remain largely unknown. Based on cell and mouse models, we found that the metastatic seeding and outgrowth of tumor cells were significantl...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Chong, Wu, Mengzhi, Zhang, Lizhen, Shang, Li-Ru, Fang, Jian-Hong, Zhuang, Shi-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216754/
https://ncbi.nlm.nih.gov/pubmed/27329720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10157
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