MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma

Neddylation is a post-translational protein modification process associated with carcinogenesis and cancer development. MLN4924, a pharmaceutical neddylation inhibitor, induces potent anti-cancer effects in multiple types of cancers. In this study, we investigated the effects of MLN4924 on human ost...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Zhang, Yi, Shi, Cheng-Cheng, Zhang, Hua-Peng, Li, Gong-Quan, Li, Shan-Shan
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216721/
https://ncbi.nlm.nih.gov/pubmed/27223074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9481
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