The post-replication repair RAD18 and RAD6 genes are involved in the prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae

7,8-Dihydro-8-oxoguanine (8-oxoG) is an abundant and mutagenic lesion produced in DNA exposed to free radicals and reactive oxygen species. In Saccharomyces cerevisiae, the OGG1 gene encodes the 8-oxoG DNA N-glycosylase/AP lyase (Ogg1), which is the functional homologue of the bacterial Fpg. Ogg1-de...

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Autores principales: de Padula, Marcelo, Slezak, Guenaelle, Auffret van Der Kemp, Patricia, Boiteux, Serge
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2004
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC521648/
https://ncbi.nlm.nih.gov/pubmed/15388802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh831
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