Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases

Cytochromes P450 metabolize arachidonic acid (AA) into two vasoactive oxylipins with opposing biologic effects: epoxyeicosatrienoic acids (EETs) and omega-(ω)-terminal hydroxyeicosatetraenoic acids (HETEs). EETs have numerous beneficial physiological effects, including vasodilation and protection ag...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Hanif, Ahmad, Edin, Matthew L., Zeldin, Darryl C., Morisseau, Christophe, Falck, John R., Nayeem, Mohammed A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215949/
https://ncbi.nlm.nih.gov/pubmed/28056085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169584
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