Anionic Oligothiophenes Compete for Binding of X‐34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain‐Derived Aβ

Deposits comprised of amyloid‐β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X‐34, a Con...

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Vydáno v:Chemistry
Hlavní autoři: Bäck, Marcus, Appelqvist, Hanna, LeVine, Harry, Nilsson, K. Peter R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215536/
https://ncbi.nlm.nih.gov/pubmed/27767229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201604583
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