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In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy

The detection of amyloid beta deposits and neurofibrillary tangles, both hallmarks of Alzheimer’s disease (AD), is key to understanding the mechanisms underlying these pathologies. Luminescent conjugated oligothiophenes (LCOs) enable fluorescence imaging of these protein aggregates. Using LCOs and m...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Calvo-Rodriguez, Maria, Hou, Steven S., Snyder, Austin C., Dujardin, Simon, Shirani, Hamid, Nilsson, K. Peter R., Bacskai, Brian J.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839235/
https://ncbi.nlm.nih.gov/pubmed/31703739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0832-1
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