Bromodomain and extra‐terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension

BACKGROUND AND OBJECTIVE: Nuclear factor kappa B (NF‐kB)‐mediated inflammatory gene expression and vascular endothelial cell proliferation/remodelling are implicated in the pathophysiology of the fatal disease, pulmonary arterial hypertension (PAH). Bromodomain and extra‐terminal (BET) proteins are...

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Detalhes bibliográficos
Publicado no:Respirology
Main Authors: Mumby, Sharon, Gambaryan, Natalia, Meng, Chao, Perros, Frederic, Humbert, Marc, Wort, S. John, Adcock, Ian M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2016
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ORIGINAL ARTICLES
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215513/
https://ncbi.nlm.nih.gov/pubmed/27539364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/resp.12872
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