Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats

Therapeutic monoclonal antibodies (mAbs) have heterogeneities in their structures. Multiple studies have reported that the variety of post-translational modifications could affect the pharmacokinetic profiles or pharmacological potencies of therapeutic mAbs. Taking into the account that the structur...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Otani, Yuki, Yonezawa, Atushi, Tsuda, Masahiro, Imai, Satoshi, Ikemi, Yasuaki, Nakagawa, Shunsaku, Omura, Tomohiro, Nakagawa, Takayuki, Yano, Ikuko, Matsubara, Kazuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215255/
https://ncbi.nlm.nih.gov/pubmed/28052138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169588
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