Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells

Gefitinib and erlotinib are anticancer agents, which inhibit epidermal growth factor receptor (EGFR) tyrosine kinase. Interstitial lung disease (ILD) occurs in patients with non-small cell lung cancer receiving EGFR inhibitors. In the present study, we examined whether gefitinib- and erlotinib-induc...

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Veröffentlicht in:PLoS One
Hauptverfasser: Koyama, Satoshi, Omura, Tomohiro, Yonezawa, Atsushi, Imai, Satoshi, Nakagawa, Shunsaku, Nakagawa, Takayuki, Yano, Ikuko, Matsubara, Kazuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545731/
https://ncbi.nlm.nih.gov/pubmed/26288223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136176
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