Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells

Gefitinib and erlotinib are anticancer agents, which inhibit epidermal growth factor receptor (EGFR) tyrosine kinase. Interstitial lung disease (ILD) occurs in patients with non-small cell lung cancer receiving EGFR inhibitors. In the present study, we examined whether gefitinib- and erlotinib-induc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Koyama, Satoshi, Omura, Tomohiro, Yonezawa, Atsushi, Imai, Satoshi, Nakagawa, Shunsaku, Nakagawa, Takayuki, Yano, Ikuko, Matsubara, Kazuo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545731/
https://ncbi.nlm.nih.gov/pubmed/26288223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136176
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