Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells

Gefitinib and erlotinib are anticancer agents, which inhibit epidermal growth factor receptor (EGFR) tyrosine kinase. Interstitial lung disease (ILD) occurs in patients with non-small cell lung cancer receiving EGFR inhibitors. In the present study, we examined whether gefitinib- and erlotinib-induc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Koyama, Satoshi, Omura, Tomohiro, Yonezawa, Atsushi, Imai, Satoshi, Nakagawa, Shunsaku, Nakagawa, Takayuki, Yano, Ikuko, Matsubara, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545731/
https://ncbi.nlm.nih.gov/pubmed/26288223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136176
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