Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats

Therapeutic monoclonal antibodies (mAbs) have heterogeneities in their structures. Multiple studies have reported that the variety of post-translational modifications could affect the pharmacokinetic profiles or pharmacological potencies of therapeutic mAbs. Taking into the account that the structur...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Otani, Yuki, Yonezawa, Atushi, Tsuda, Masahiro, Imai, Satoshi, Ikemi, Yasuaki, Nakagawa, Shunsaku, Omura, Tomohiro, Nakagawa, Takayuki, Yano, Ikuko, Matsubara, Kazuo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215255/
https://ncbi.nlm.nih.gov/pubmed/28052138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169588
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki