Quantitative [(18)F]-FMISO- PET imaging shows reduction of hypoxia following trastuzumab in a murine model of HER2+ breast cancer

PURPOSE: Evaluation of [(18)F]-FMISO-PET imaging as a metric for evaluating early response to trastuzumab therapy with histological validation in a murine model of HER2+ breast cancer. PROCEDURES: Mice with BT474, HER2+ tumors, were imaged with [(18)F]-FMISO-PET during trastuzumab therapy. Pimonidaz...

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發表在:Mol Imaging Biol
Main Authors: Sorace, Anna G., Syed, Anum K., Barnes, Stephanie L., Quarles, C. Chad, Sanchez, Violeta, Kang, Hakmook, Yankeelov, Thomas E.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214951/
https://ncbi.nlm.nih.gov/pubmed/27506906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-016-0994-1
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