Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/human PK but also to evaluating the drug-drug interaction (DDI) liability at the drug discovery or development stage. Herein, we describe a case study to...

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Detalles Bibliográficos
Publicado en:Korean J Physiol Pharmacol
Main Authors: Park, Min-Ho, Shin, Seok-Ho, Byeon, Jin-Ju, Lee, Gwan-Ho, Yu, Byung-Yong, Shin, Young G.
Formato: Artigo
Idioma:Inglês
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214901/
https://ncbi.nlm.nih.gov/pubmed/28066147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2017.21.1.107
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