Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective

The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical industry, significant resources are invested to predict and characterize a clinically relevant food effect. Here, the predictive per...

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Udgivet i:AAPS J
Main Authors: Riedmaier, Arian Emami, DeMent, Kevin, Huckle, James, Bransford, Phil, Stillhart, Cordula, Lloyd, Richard, Alluri, Ravindra, Basu, Sumit, Chen, Yuan, Dhamankar, Varsha, Dodd, Stephanie, Kulkarni, Priyanka, Olivares-Morales, Andrés, Peng, Chi-Chi, Pepin, Xavier, Ren, Xiaojun, Tran, Thuy, Tistaert, Christophe, Heimbach, Tycho, Kesisoglou, Filippos, Wagner, Christian, Parrott, Neil
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7520419/
https://ncbi.nlm.nih.gov/pubmed/32981010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00508-2
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