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CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats
The molecular mechanisms underlying age-related cognitive deficits are not yet fully elucidated. In aged animals, a decrease in the intrinsic excitability of CA1 pyramidal neurons is believed to contribute to age-related cognitive impairments. Increasing activity of the transcription factor cAMP res...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5214885/ https://ncbi.nlm.nih.gov/pubmed/28051768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19358 |
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