Increasing CREB Function in the CA1 Region of Dorsal Hippocampus Rescues the Spatial Memory Deficits in a Mouse Model of Alzheimer's Disease

The principal defining feature of Alzheimer's disease (AD) is memory impairment. As the transcription factor CREB (cAMP/Ca(2+) responsive element-binding protein) is critical for memory formation across species, we investigated the role of CREB in a mouse model of AD. We found that TgCRND8 mice...

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Главные авторы: Yiu, Adelaide P, Rashid, Asim J, Josselyn, Sheena A
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2011
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176558/
https://ncbi.nlm.nih.gov/pubmed/21734652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.107
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